منابع مشابه
Colorectal cancer carcinogenesis: a review of mechanisms.
Colorectal cancer (CRC) is the second most common cancer in women and the third most common in men globally. CRC arises from one or a combination of chromosomal instability, CpG island methylator phenotype, and microsatellite instability. Genetic instability is usually caused by aneuploidy and loss of heterozygosity. Mutations in the tumor suppressor or cell cycle genes may also lead to cellula...
متن کاملMultistage carcinogenesis and the incidence of colorectal cancer.
We use general multistage models to fit the age-specific incidence of colorectal cancers in the Surveillance, Epidemiology, and End Results registry, which covers approximately 10% of the U.S. population, while simultaneously adjusting for birth cohort and calendar year effects. The incidence of colorectal cancers in the Surveillance, Epidemiology, and End Results registry is most consistent wi...
متن کاملRole of Molecular Biomarkers in Colorectal Cancer
Colorectal cancer (CRC) is amongst the most widespread cancers and is a most common cause of cancer associated mortality universally. Since previous decades, it has been cleared that CRC develops owing to the buildup of a series of genetic and epigenetic changes in the normal colonic epithelium. Regardless of the current development in surgery and therapies, overall survival of end stage CRC pa...
متن کاملMolecular Mechanisms of Colorectal Carcinogenesis
K.M. Haigis (ed.), Molecular Pathogenesis of Colorectal Cancer, DOI 10.1007/978-1-4614-8412-7_2, © Springer Science+Business Media New York 2013 Abstract Colorectal cancer (CRC) presents in three major forms: inherited, sporadic, and familial. Although the mechanisms underlying familial CRC are poorly understood, a large body of evidence suggests that inherited and sporadic CRC are caused by se...
متن کاملMyeloperoxidase-positive cell infiltration in colorectal carcinogenesis as indicator of colorectal cancer risk.
Colorectal mucosa is targeted by toxic agents, which can initiate or promote colon cancer. The mechanism of damage might be a focal irritation with loss of normal epithelial cell barrier function. Genetic alterations in tumors may also affect host inflammatory response. The aim of this study was to define the extent of inflammation in colorectal mucosa, along colorectal carcinogenesis, and in m...
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ژورنال
عنوان ژورنال: Veterinary Quarterly
سال: 1998
ISSN: 0165-2176,1875-5941
DOI: 10.1080/01652176.1998.9694981